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· 58min atrás

[Video] HealthShare Vision & Roadmap - Fueling Faster AI Adoption Through Trusted Health Data

Hey Developers,

Enjoy the new video on InterSystems Developers YouTube

⏯ HealthShare Vision & Roadmap - Fueling Faster AI Adoption Through Trusted Health Data @ READY 2025

Trusted data powers GenAI—but it’s equally essential for driving meaningful analytics and applications. Meet the new Head of Product for HealthShare and hear the vision for how HealthShare will build trust in your data and unlock new opportunities for your organization.

🗣 Presenter: Sean Kennedy, Head of Product, HealthShare at InterSystems

Want to stay ahead? Watch the video and subscribe to continue learning!👍

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Artigo
· 5 hr atrás 6min de leitura

Varicocele: Causes, Symptoms, Diagnosis, and Treatment Options

Varicocele is a common medical condition affecting the veins of the scrotum, the pouch of skin that holds the testicles. It occurs when the veins inside the scrotum become enlarged and twisted, similar to varicose veins seen in the legs. Although varicocele is often painless and harmless, it can sometimes lead to discomfort, testicular damage, and fertility problems in men.

Varicocele is most commonly diagnosed in adolescents and adult men, particularly between the ages of 15 and 35. According to medical studies, around 15% of all men and up to 40% of men with infertility are affected by varicocele. Understanding varicocele is important because early diagnosis and proper treatment can prevent complications and improve reproductive health.

This article provides a complete overview of varicocele, including its causes, symptoms, risks, diagnosis, treatment options, and prevention tips.


What Is Varicocele?

A varicocele is an abnormal enlargement of the pampiniform plexus, a network of veins that drains blood from the testicles. These veins play an important role in regulating testicular temperature, which is essential for healthy sperm production.

When the valves inside these veins do not work properly, blood flows backward and pools in the veins. This leads to increased pressure, vein dilation, and overheating of the testicles, which can affect sperm quality and testosterone production.

Varicoceles usually develop slowly and are most often found on the left side of the scrotum due to anatomical differences in vein drainage. However, they can occur on the right side or both sides as well.


Types and Grades of Varicocele

Varicocele is classified into different grades based on its size and severity:

Grade 1 (Small Varicocele)

  • Not visible
  • Can only be detected during a physical exam when the patient strains (Valsalva maneuver)
  • Usually asymptomatic

Grade 2 (Moderate Varicocele)

  • Not visible but easily felt during examination
  • May cause mild discomfort or heaviness

Grade 3 (Large Varicocele)

  • Clearly visible through the scrotal skin
  • Often described as a “bag of worms”
  • More likely to cause pain, testicular shrinkage, or infertility

Causes of Varicocele

The exact cause of varicocele is not always clear, but the most common reasons include:

Faulty Vein Valves

Veins have one-way valves that help blood flow back toward the heart. If these valves fail, blood pools in the veins, causing them to enlarge.

Anatomical Factors

The left testicular vein drains into the left renal vein at a right angle, which increases pressure and makes varicocele more common on the left side.

Increased Pressure in the Abdomen

Activities or conditions that increase abdominal pressure—such as heavy lifting, chronic coughing, constipation, or prolonged standing—may worsen varicocele.

Hormonal and Blood Flow Changes

Abnormal blood flow and hormonal imbalance may also contribute to vein dilation and testicular dysfunction.


Symptoms of Varicocele

Many men with varicocele experience no symptoms, and the condition is often discovered during a routine physical exam or fertility evaluation. When symptoms do occur, they may include:

  • Dull or aching pain in the scrotum
  • Heaviness or dragging sensation in the testicles
  • Pain that worsens after standing or physical activity
  • Relief when lying down
  • Visible or enlarged veins in the scrotum
  • One testicle appearing smaller than the other
  • Difficulty conceiving a child

Pain associated with varicocele is usually mild but can become persistent in severe cases.


Is Varicocele Dangerous?

Varicocele itself is not life-threatening, but it can cause significant health concerns if left untreated:

Impact on Fertility

Varicocele is one of the leading causes of male infertility. It can:

  • Reduce sperm count
  • Decrease sperm motility
  • Affect sperm shape and DNA quality

Testicular Atrophy

Prolonged varicocele may cause shrinkage of the affected testicle due to tissue damage.

Hormonal Imbalance

Varicocele can affect testosterone production, potentially leading to fatigue, low libido, and reduced muscle mass.

Early treatment can prevent or reverse many of these effects.


Varicocele and Male Infertility

Varicocele affects fertility by increasing testicular temperature and disrupting oxygen supply. Sperm production requires a temperature slightly lower than body temperature. When veins are enlarged, heat regulation is impaired, leading to poor sperm development.

Men with varicocele may experience:

  • Low sperm count (oligospermia)
  • Poor sperm movement (asthenospermia)
  • Abnormal sperm shape (teratospermia)

Treating varicocele has been shown to improve semen parameters and increase natural pregnancy rates in many cases.


Diagnosis of Varicocele

Physical Examination

A urologist examines the scrotum while the patient is standing and may ask them to strain. Enlarged veins can often be felt or seen.

Ultrasound Imaging

Scrotal ultrasound is the most accurate diagnostic test. It helps:

  • Confirm varicocele
  • Measure vein size
  • Assess blood flow
  • Evaluate testicular size and damage

Semen Analysis

For men with fertility concerns, semen analysis is performed to evaluate sperm count, motility, and morphology.

Hormonal Tests

Blood tests may be done to measure testosterone and other reproductive hormones.


Treatment Options for Varicocele

Varicocele Treatment depends on the severity of symptoms, fertility goals, and testicular health. Mild cases may not require immediate intervention.

1. Conservative Management

Recommended for asymptomatic or mild cases:

  • Pain relievers (NSAIDs)
  • Scrotal support
  • Avoiding prolonged standing
  • Lifestyle modifications

2. Varicocele Surgery (Varicocelectomy)

Surgery is advised when varicocele causes pain, infertility, or testicular atrophy.

Open Surgery

  • Performed through a small groin or abdominal incision
  • Damaged veins are tied off
  • Requires short recovery time

Microsurgical Varicocelectomy

  • Most effective and preferred method
  • Uses a microscope for precision
  • Lowest recurrence and complication rates

Laparoscopic Surgery

  • Minimally invasive
  • Uses small incisions and a camera
  • Faster recovery than open surgery

3. Varicocele Embolization

A non-surgical procedure performed by an interventional radiologist:

  • A catheter is inserted through a vein
  • Coils or agents block the affected veins
  • Blood reroutes to healthy veins
  • Quick recovery and minimal pain

Recovery After Varicocele Treatment

Most patients recover within 1–2 weeks after surgery or embolization. Common recovery guidelines include:

  • Avoid heavy lifting for 2–4 weeks
  • Wear scrotal support
  • Take prescribed medications
  • Follow up with your doctor
  • Repeat semen analysis after 3–6 months

Sperm improvement usually takes several months because sperm production cycles last about 70–90 days.


Success Rates of Varicocele Treatment

  • Pain relief: 80–90%
  • Improvement in semen parameters: 60–70%
  • Increased pregnancy rates: 30–50%
  • Low recurrence with microsurgery: <5%

Results vary depending on age, severity, and overall reproductive health.


Can Varicocele Be Prevented?

There is no guaranteed way to prevent varicocele, but the following may help reduce risk or progression:

  • Avoid excessive heavy lifting
  • Maintain healthy body weight
  • Treat chronic constipation or coughing
  • Avoid prolonged standing
  • Seek early medical advice for scrotal discomfort

When to See a Doctor

Consult a urologist if you experience:

  • Persistent scrotal pain
  • Visible scrotal swelling
  • Difficulty conceiving
  • Testicular size changes
  • Low testosterone symptoms

Early evaluation ensures better outcomes and peace of mind.


Frequently Asked Questions (FAQs)

Is varicocele common?

Yes, it affects about 1 in 6 men.

Can varicocele go away on its own?

No, it usually does not resolve without treatment.

Does varicocele always cause infertility?

No, many men with varicocele can father children naturally.

Is surgery painful?

Modern techniques are minimally invasive and well tolerated.

Can varicocele come back?

Recurrence is rare, especially with microsurgical treatment.


Conclusion

Varicocele is a common but often overlooked condition that can affect male fertility, hormonal balance, and testicular health. While many cases are harmless, untreated varicocele can lead to long-term complications. Early diagnosis, proper evaluation, and personalized treatment can significantly improve quality of life and reproductive outcomes.

If you experience symptoms or fertility concerns, consulting a qualified urologist is the best step toward effective management and recovery.

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Artigo
· 6 hr atrás 4min de leitura

Quando considerar o uso de useIrisFsGroup em suas implantações do IKO

Se você olhar o arquivo values.yaml do Helm chart do IKO, você encontrará:

useIrisFsGroup: false 

Vamos detalhar o que isso é e em quais situações você pode querer configurá-lo como true.

FsGroup se refere ao grupo do sistema de arquivos.

Por padrão, os volumes do Kubernetes pertencem ao usuário root, mas precisamos que o IRIS seja o dono de seus arquivos (o IRIS em containers é instalado sob o usuário irisowner). Para contornar isso, utilizamos um de dois métodos:

1) initContainers

Os initContainers são executados antes dos containers da aplicação (como o IRIS) em um pod. Eles geralmente preparam o ambiente para a aplicação e, em seguida, são executados até a conclusão e encerram. O initContainer é executado como root antes do IRIS e executa:

chown -R irisowner:irisowner /irissys/*

SecurityContext é, por padrão, configurado como:

RunAsUser: 51773
RunAsGroup: 51773
RunAsNonRoot: true

para o pod. E vemos que 51773 é o ID de usuário e de grupo do irisowner:

$ id
uid=51773(irisowner) gid=51773(irisowner) groups=51773(irisowner)

2) Montar volumes com uma determinada propriedade de grupo

Alguns ambientes podem restringir a execução de qualquer container como root, por exemplo por meio de Security Context Constraints no OpenShift. Nesse caso, não podemos nem mesmo executar um initContainer como root e será necessário que os volumes recebam a propriedade correta do sistema de arquivos no momento da montagem. Para isso, implante o InterSystems Kubernetes Operator com

useIrisFsGroup: true 

em /chart/iris-operator/values.yaml file.

Agora seus pods serão implantados sem initContainers.

Como ressalva, se você quiser configurar sidecars, será necessária uma etapa extra. Você não pode usar o sidecar padrão do Apache/NGINX. Você encontrará este problema:

>> kubectl get pods
NAME                                              READY   STATUS    RESTARTS      AGE
intersystems-iris-operator-amd-76b75f6b48-7lnw2   1/1     Running   0             43m
iris-data-0-0                                     1/2     Error     2 (22s ago)   2m

o que resultará em um CrashLoopBackOff. Uma análise mais detalhada mostra que, quando o sidecar padrão do gateway web Apache/NGINX está presente, o useIrisFsGroup não é considerado. Isso acontece porque esses containers do Apache/NGINX, nesse caso o sidecar, são executados como root. O IRIS não é executado como root e, portanto, não consegue acessar seus diretórios, causando o problema.

irisowner@iris-data-0-0:/irissys$ ls -l
total 16
drwxrwxrwx 3 root root  107 Mar 31 14:28 cpf
drwxr-xr-x 3 root root 4096 Mar 31 14:21 data
drwxr-xr-x 3 root root 4096 Mar 31 14:21 journal1
drwxr-xr-x 3 root root 4096 Mar 31 14:21 journal2
drwxrwxrwt 3 root root  100 Mar 31 14:28 key
drwxr-xr-x 3 root root 4096 Mar 31 14:21 wij

IRIS falha com o erro:

[ERROR] Command "iris start IRIS quietly" exited with status 256
03/31/25-14:41:06:870 (795) 3 [Utility.Event] Error while moving data directories ERROR #5001: Cannot create target: /irissys/data/IRIS/

Em vez disso, devemos usar a imagem do gateway web que não roda como root (já que queremos que todas as nossas imagens sejam executadas como não-root). Isso implica um gateway web mais restrito. Também precisamos garantir que o security context seja adicionado para reforçar essa condição. Devemos declarar explicitamente:

securityContext:
  runAsUser: 51773
  runAsGroup: 51773
  runAsNonRoot: true
  fsGroup: 51773

no seu data/compute nodes.

Um exemplo de YAML para o nosso IrisCluster CRD reunindo tudo isso pode ser visto abaixo.

apiVersion: intersystems.com/v1alpha1
kind: IrisCluster
metadata:
  name: iris
spec:
  licenseKeySecret:
    name: iris-key-secret
  configSource:
    name: iris-cpf
  imagePullSecrets:
    - name: intersystems-pull-secret
  topology:
    data:
      image: containers.intersystems.com/intersystems/irishealth:2025.1
      compatibilityVersion: "2025.1.0"
      mirrored: true
      podTemplate:
        spec:
          resources:
            requests:
              memory: "4Gi"
              cpu: "2"
            limits:
              memory: "4Gi"
              cpu: "2"
          securityContext:
            runAsUser: 51773
            runAsGroup: 51773
            runAsNonRoot: true
            fsGroup: 51773
      webgateway:
        image: containers.intersystems.com/intersystems/webgateway-lockeddown:2025.1
        type: apache-lockeddown
        applicationPaths:
          - /csp/sys
          - /csp/user
          - /csp/broker
          - /api
          - /isc
          - /oauth2
          - /ui
          - /csp/healthshare
        loginSecret:
          name: iris-webgateway-secret
    webgateway:
      replicas: 1
      image: containers.intersystems.com/intersystems/webgateway-lockeddown:2025.1
      type: apache-lockeddown
      podTemplate:
        spec:
          resources:
            requests:
              memory: "2Gi"
              cpu: "1"
            limits:
              memory: "2Gi"
              cpu: "1"
      applicationPaths:
        - /csp/sys
        - /csp/user
        - /csp/broker
        - /api
        - /isc
        - /oauth2
        - /ui
        - /csp/healthshare
      alternativeServers: LoadBalancing
      loginSecret:
        name: iris-webgateway-secret
    arbiter:
      image: containers.intersystems.com/intersystems/arbiter:2025.1
  serviceTemplate:
    spec:
      type: ClusterIP

Happy YAMLing

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Pergunta
· 11 hr atrás

HealthShare - FHIR gateway

I'm new to HealthShare. I've installed a demo using the HS.Util.Installer helper, now I'm playing with its FHIR Gateway (which is the HSFHIR namespace). When I try to create a new resource of type Patient using HTTP POST, HealthShare responses with

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InterSystems Oficial
· 19 hr atrás

InterSystems 云服务 - 版本 25.24.2 发布说明(2025 年 11 月)

概述

本版本对存储的可扩展性和性能进行了重大改进,对所有产品的操作系统进行了重大升级,并推出了新的 FHIR 服务器默认版本。这些更新共同增强了系统的可靠性、灵活性和安全性,同时确保了平台的长期可支持性。


新功能和增强功能

类别

功能/改进

详细信息

存储 增强的 LVM 支持(条带或线性) 增加了对 LVM 配置的支持,允许使用条带式或线性卷布局进行部署,以提高性能和灵活性。
  选择使用 LVM 配置 客户现在可以在配置过程中选择使用基于 LVM 的存储,从而更好地控制卷管理和数据布局。
  扩大最大存储限制 每个部署支持的最大存储容量增至8 PB,可支持大规模数据工作负载和长期增长。
操作系统 Red Hat Enterprise Linux 9.6 升级 所有 InterSystems 云产品都从 RHEL 9.0 升级到了RHEL 9.6,提供了更好的内核性能、更强的安全性和更长的生命周期支持。
FHIR 服务器 默认版本 2025.11.0

FHIR Server2025.11.0 现在是所有新部署的默认版本,在可扩展性、互操作性和数据管理方面都有改进。

有关详细信息,请参阅 FHIR Server 2025.11.0 发行说明。


建议采取的行动


支持

有关此版本的更多信息或帮助,请通过 iService 或云服务门户联系 InterSystems 云服务支持。

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